In 2010, the Memorial of National Literature acquired premises (former barracks in Litoměřice) from the Ministry of Defence of the Czech Republic for the purpose of building the Central Depository. In 2011-2012, a project was created and the first stage of the reconstruction took place in 2014-2015. At the beginning of 2016, the collections were moved to building No. 1 (the depository of the literary archive) from the rented premises in Staré Hrady and Duchcov Castle. At the end of 2019, the second depository building for the Department of Art Collections was approved. The Central Depository in Litoměřice houses modern depository technology, compact shelving and specialised rooms for storing unstable materials (photo archive, audio-video archive and other magnetic records). The building also includes rooms for the organisation of large archive units, a digitisation and restoration workplace, a service workplace and a research room.

The buildings, originally the site of artillery barracks, were built before 1914 and served as barracks during the First Republic. In 1944-1945, prisoners working in the nearby Richard underground factory complex were interned here. After the war, the Czechoslovak People's Army and then the Army of the Czech Republic operated here and used it as a barracks until the late 1990s.